This study sought to assess the implementation of these quality assurance principles and guidelines of Inter-University Council of East Africa (IUCEA) at the University of Nairobi with specific focus on Governance and Management of the University and academic staff. It was grounded on the General System Theory (GST) originally developed by Ludwig Von Bertalanffy and applied the convergent parallel mixed methods design. Various instruments were developed, pilot-tested, revised and administered to collect data from the respondents. Data was analysed using both qualitative and quantitative procedures. The study revealed that a majority of the academic staff were qualified to teach in university according to the prerequisite of the Commission for University Education and the IUCEA guidelines. The findings also indicate that most of the academic staff was PhD holders. On incentives and staff remuneration, majority of the lecturers maintained that there were no incentives given and that the Government and the University management and a majority of the lecturers, deans and HoDs registered their dissatisfactions as far as the working conditions were concerned.